Protein Details: Short transient receptor potential channel 1

Protein ID

ICDB_Pro_0561

Protein Name

Short transient receptor potential channel 1

Gene Name

TRPC1; TRP1

Organism

Homo sapiens (Human)

Length

793 amino acids

AlphaFoldDB

AF-P48995-F1-model_v4.pdb

Function

Sequence

MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Anemia;Congenital Dyserythropoietic;Type Iv and Autosomal Recessive Nonsyndromic Deafness

Location

Seems to be ubiquitous

DOI ID

10.1016/0014-5793(95)01038-g; 10.1073/pnas.92.21.9652; 10.1016/s0896-6273(00)80145-2; 10.1101/gr.2596504; 10.1016/s0092-8674(00)80302-5; 10.1074/jbc.275.16.11934; 10.1161/01.res.88.1.84; 10.1073/pnas.102596199; 10.1074/jbc.m313975200; 10.1074/jbc.m500391200; 10.1016/j.ceca.2007.07.009; 10.1016/j.neuron.2009.09.025

RefSeq

NP_001238774.1 [P48995-1]; NP_003295.1 [P48995-2]